Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.10 extracted from

  • Mukkamala, D.; No, J.H.; Cass, L.M.; Chang, T.K.; Oldfield, E.
    Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data (2008), J. Med. Chem., 51, 7827-7833.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Plasmodium vivax

Inhibitors

Inhibitors Comment Organism Structure
(1-hydroxyheptane-1,1-diyl)bis(phosphonic acid)
-
Plasmodium vivax
3-(2-hydroxy-2,2-diphosphonoethyl)-2H-imidazo[1,2-a]pyridin-4-ium
-
Plasmodium vivax
[(octylamino)methanediyl]bis(phosphonic acid)
-
Plasmodium vivax
[1-hydroxy-3-[(3-phenylpropyl)amino]propane-1,1-diyl]bis(phosphonic acid)
-
Plasmodium vivax
[1-hydroxy-3-[methyl(2-phenylethyl)amino]propane-1,1-diyl]bis(phosphonic acid)
-
Plasmodium vivax
[1-hydroxy-3-[methyl(4-phenylbutyl)amino]propane-1,1-diyl]bis(phosphonic acid)
-
Plasmodium vivax
[2-(3-chlorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
-
Plasmodium vivax
[2-(3-fluorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
-
Plasmodium vivax

Organism

Organism UniProt Comment Textmining
Plasmodium vivax
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0004
-
pH 7.4, 22°C Plasmodium vivax [1-hydroxy-3-[methyl(2-phenylethyl)amino]propane-1,1-diyl]bis(phosphonic acid)
0.00045
-
pH 7.4, 22°C Plasmodium vivax [1-hydroxy-3-[(3-phenylpropyl)amino]propane-1,1-diyl]bis(phosphonic acid)
0.00049
-
pH 7.4, 22°C Plasmodium vivax [(octylamino)methanediyl]bis(phosphonic acid)
0.00061
-
pH 7.4, 22°C Plasmodium vivax [1-hydroxy-3-[methyl(4-phenylbutyl)amino]propane-1,1-diyl]bis(phosphonic acid)
0.00063
-
pH 7.4, 22°C Plasmodium vivax (1-hydroxyheptane-1,1-diyl)bis(phosphonic acid)
0.00063
-
pH 7.4, 22°C Plasmodium vivax [2-(3-chlorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
0.00063
-
pH 7.4, 22°C Plasmodium vivax [2-(3-fluorophenyl)-1-hydroxyethane-1,1-diyl]bis(phosphonic acid)
0.00064
-
pH 7.4, 22°C Plasmodium vivax 3-(2-hydroxy-2,2-diphosphonoethyl)-2H-imidazo[1,2-a]pyridin-4-ium