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Literature summary for 2.5.1.10 extracted from

  • Li, L.; Chen, G.P.; Yang, Y.; Ye, Y.; Yao, L.; Hu, S.J.
    Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats (2010), Biochem. Pharmacol., 79, 399-406.
    View publication on PubMed

Application

Application Comment Organism
medicine chronic treatment with an FPPS inhibitor attenuates the development of cardiac hypertrophy and fibrosis Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
alendronate twelve weeks of alendronate treatment attenuates the left ventricular weight to body weight ratio, hydroxyproline content, collagen deposition in the interstitia, and gene expression of atrial natriuretic peptide, B-type natriuretic peptide, and procollagen type I/III in the SHR left ventricle, all of which are significantly higher in spontaneously hypertensive rats than in control rats. Long-term treatment with inhibitor significantly reduces RhoA activation, ERK phosphorylation, and TGF-b1 expression in the spontaneously hypertensive rat left ventricle, all ofwhich were upregulated more in spontaneously hypertensive rats than in control rats Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining

General Information

General Information Comment Organism
physiological function twelve weeks of treatment with inhibitor alendronate attenuates the left ventricular weight to body weight ratio, hydroxyproline content, collagen deposition in the interstitia, and gene expression of atrial natriuretic peptide, B-type natriuretic peptide, and procollagen type I/III in the SHR left ventricle, all of which are significantly higher in spontaneously hypertensive rats than in control rats. Long-term treatment with inhibitor significantly reduces RhoA activation, ERK phosphorylation, and TGF-b1 expression in the spontaneously hypertensive rat left ventricle, all ofwhich were upregulated more in spontaneously hypertensive rats than in control rats Rattus norvegicus