Literature summary for 2.4.99.20 extracted from

Graeff, R.; Liu, Q.; Kriksunov, I.A.; Hao, Q.; Lee, H.C.
Acidic residues at the active sites of CD38 and ADP-ribosyl cyclase determine nicotinic acid adenine dinucleotide phosphate (NAADP) synthesis and hydrolysis activities (2006), J. Biol. Chem., 281, 28951-28957.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
complex of isoform CD38 with substrate NMN shows that the nicotinamide moiety is in close contact with Glu146 at 3.27 A and Asp155 at 2.52 A. Residue Asp147 is situated and directed away from the bound substrate	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D147V	mutation has minimal effects on pH-dependence of the enzyme	Homo sapiens
D155N	mutation eliminates the strong pH dependence of the catalyzed reactions	Homo sapiens
D155Q	mutation eliminates the strong pH dependence of the catalyzed reactions	Homo sapiens
D155Q	mutation preserves the strong pH dependence of the catalyzed reactions	Homo sapiens
E146A	mutation eliminates the strong pH dependence of the catalyzed reactions	Homo sapiens
E146G	mutation eliminates the strong pH dependence of the catalyzed reactions	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P28907	-	-

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Release 2023.1 (January 2023)