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Literature summary for 2.4.99.19 extracted from

  • Ihssen, J.; Kowarik, M.; Wiesli, L.; Reiss, R.; Wacker, M.; Thoeny-Meyer, L.
    Structural insights from random mutagenesis of Campylobacter jejuni oligosaccharyltransferase PglB (2012), BMC Biotechnol., 12, 67.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine application for protein glycosylation in recombinant bacteria in the production of potent conjugate vaccines where polysaccharide antigens of pathogenic bacteria are covalently bound to immunogenic carrier proteins Campylobacter jejuni

Cloned(Commentary)

Cloned (Comment) Organism
gene pglB, functional expression in Escherichia coli Campylobacter jejuni

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
tritrans,heptacis-undecaprenyl diphosphooligosaccharide + [protein]-L-asparagine Campylobacter jejuni
-
tritrans,heptacis-undecaprenyl diphosphate + [protein]-L-asparagine-oligosaccharide a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to protein L-asparagine ?

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni
-
gene pglB
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tritrans,heptacis-undecaprenyl diphosphooligosaccharide + [protein]-L-asparagine
-
Campylobacter jejuni tritrans,heptacis-undecaprenyl diphosphate + [protein]-L-asparagine-oligosaccharide a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to protein L-asparagine ?

Synonyms

Synonyms Comment Organism
N-oligosaccharyltransferase
-
Campylobacter jejuni
oligosaccharyltransferase
-
Campylobacter jejuni
PglB
-
Campylobacter jejuni

General Information

General Information Comment Organism
additional information structure-function relationships for the periplasmic domain of the N-oligosaccharyltransferase PglB, overview Campylobacter jejuni