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Literature summary for 2.4.2.9 extracted from

  • Mainguet, S.E.; Gakiere, B.; Majira, A.; Pelletier, S.; Bringel, F.; Guerard, F.; Caboche, M.; Berthome, R.; Renou, J.P.
    Uracil salvage is necessary for early Arabidopsis development (2009), Plant J., 60, 280-291.
    View publication on PubMed
Search for more literature for 2.4.2.9

Cloned(Commentary)

Cloned (Comment) Organism
gene UPP, DNA and amino acid sequence determination and analysis, gene structure, sequence comparison, and phylogenetic analysis, Comparison to uracil kinase-like proteins possessing UPRT domains. The single nuclear gene encoding UPP targeted to plastids is responsible for almost all UPRT activity in Arabidopsis thaliana Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information construction of T-DNA insertion enzyme mutants, inability to salvage uracil caused a lightdependent dramatic pale-green to albino phenotype, dwarfism and the inability to produce viable progeny in loss-of-function mutants, plastid biogenesis and starch accumulation are affected in all tissues, with the exception of stomata, phenotypes, overview. A graduation in the tolerance to 5-fluorouracil is observed among the upp(+/) heterozygous plants. Functional complementation of the enzyme-deficient Escherichia coli mutant strain BM604, overview. No significant decrease in UPRT activity is measured in the mutants disrupted at uracil kinase-like proteins UKL loci Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
chloroplast
-
 Arabidopsis thaliana 9507
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uracil + 5-phospho-alpha-D-ribose 1-diphosphate Arabidopsis thaliana
-
 UMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q9M336 UPP, putative; gene upp
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
uracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Arabidopsis thaliana UMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
UPRT
-
 Arabidopsis thaliana

General Information

General Information Comment Organism
metabolism the enzyme is involved in the metabolism of uracil and related compounds in plants catalyzing the uracil salvage, which is of major importance for plant development, overview Arabidopsis thaliana
physiological function UPRTs, on-essential, energy-saving enzymes, are involved in the salvage of pyrimidines by catalyzing the formation of uridine monophosphate from uracil and phosphoribosylpyrophosphate. Uracil salvage is of major importance for plant development, especially early development Arabidopsis thaliana