Literature summary for 2.4.2.9 extracted from

Tanaka, T.; Duflot-Dancer, A.; Tiraby, M.; Piccoli, C.; Tiraby, G.; Yamasaki, H.; Mesnil, M.
Bystander effect from cytosine deaminase and uracil phosphoribosyl transferase genes in vitro: a partial contribution of gap junctions (2009), Cancer Lett., 282, 43-47.

Cloned(Commentary)

Cloned (Comment)	Organism
co-expression of gene CodA, encoding cytosine deaminase, and gene upp, encoding uracil phosphoribosyl transferase, renders HeLa cells sensitive to 5-fluorocytosine, converted to toxic 5-fluorouracil by cytosine deaminase, and enhanced a bystander effect mediated by a gap junction mechanism, 1% cytosine deaminase+-UPP+ cells are able to kill 40% of the cell population if the cells are communicating	Homo sapiens

Cloned (Comment)

Organism

co-expression of gene CodA, encoding cytosine deaminase, and gene upp, encoding uracil phosphoribosyl transferase, renders HeLa cells sensitive to 5-fluorocytosine, converted to toxic 5-fluorouracil by cytosine deaminase, and enhanced a bystander effect mediated by a gap junction mechanism, 1% cytosine deaminase+-UPP+ cells are able to kill 40% of the cell population if the cells are communicating

Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	gene upp	-

Synonyms

Synonyms	Comment	Organism
UPP	-	Homo sapiens
uracil phosphoribosyl transferase	-	Homo sapiens

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Release 2023.1 (January 2023)