Literature summary for 2.4.2.9 extracted from

Khatri, A.; Zhang, B.; Doherty, E.; Chapman, J.; Ow, K.; Pwint, H.; Martiniello-Wilks, R.; Russell, P.J.
Combination of cytosine deaminase with uracil phosphoribosyl transferase leads to local and distant bystander effects against RM1 prostate cancer in mice (2006), J. Gene Med., 8, 1086-1096.

Search for more literature for 2.4.2.9

Cloned(Commentary)

Cloned (Comment)	Organism
expression of the fusion gene CDUPRT, combining cytosine deaminase combined with uracil phosphoribosyl transferase, in RM1 cancer cells in a gene therapeutic approach, overview	Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	expression of fusion protein cytosine deaminase combined with uracil phosphoribosyl transferase leads to local and distant bystander effects against intraprostatic mouse androgen-refractory prostate, RM1, tumors in immunocompetent mice, CDUPRT-GDEPT expression significantly suppresses the aggressive growth of RM1 prostate tumors and lung pseudo-metastases via immune mechanisms involving necrosis and apoptosis, overview	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate	Mus musculus	recombinant fusion enzyme in RM1 tumors of lung, spleen, heart, and prostate	5-fluoro-UMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate	recombinant fusion enzyme in RM1 tumors of lung, spleen, heart, and prostate	Mus musculus	5-fluoro-UMP + diphosphate	-	?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate	recombinant fusion enzyme	Mus musculus	5-fluoro-UMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
uracil phosphoribosyl transferase	-	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)