KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0012 | - |
adenine | pH 7.4, temperature not specified in the publication | Leishmania donovani | |
1.5 | - |
hypoxanthine | pH 7.4, temperature not specified in the publication | Leishmania donovani |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
adenine + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Leishmania donovani | AMP + diphosphate | - |
? | |
hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate | at about 5.7% of the conversion rate for adenine | Leishmania donovani | IMP + diphosphate | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | amplification of adenine phosphoribosyltransferase suppresses the conditionally lethal growth and virulence phenotype of Leishmania donovani mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases. Transfection of mutants lacking both hypoxanthine-guanine and xanthine phosphoribosyltransferases with an adenine phosphoribosyltransferase episome recapitulates the suppressor phenotype in vitro and enables growth on 6-oxypurines. Hypoxanthine is an inefficient substrate for adenine phosphoribosyltransferase | Leishmania donovani |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00035 | - |
hypoxanthine | pH 7.4, temperature not specified in the publication | Leishmania donovani | |
1090 | - |
adenine | pH 7.4, temperature not specified in the publication | Leishmania donovani |