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Literature summary for 2.4.2.7 extracted from

  • Queen, S.A.; Vander Jagt, D.L.; Reyes, P.
    Characterization of adenine phosphoribosyltransferase from the human malaria parasite, Plasmodium falciparum (1989), Biochim. Biophys. Acta, 996, 160-165.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,6-diaminopurine competitive Plasmodium falciparum
6-Mercaptopurine competitive Plasmodium falciparum
Cd2+
-
Plasmodium falciparum
Co2+
-
Plasmodium falciparum
Hg2+
-
Plasmodium falciparum
additional information no inhibition by iodoacetamide, DTNB Plasmodium falciparum
N-ethylmaleimide no inhibition Plasmodium falciparum
p-chloromercuribenzoate no inhibition Plasmodium falciparum
Zn2+ weak Plasmodium falciparum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0007
-
5-phospho-alpha-D-ribose 1-diphosphate
-
Plasmodium falciparum
0.0008
-
adenine
-
Plasmodium falciparum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
18000
-
gel filtration Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
trophozoite
-
Plasmodium falciparum
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00000004
-
-
Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenine + 5-phospho-alpha-D-ribose 1-diphosphate
-
Plasmodium falciparum AMP + diphosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Plasmodium falciparum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.7
-
Mercaptopurine
-
Plasmodium falciparum
1
-
2,6-diaminopurine
-
Plasmodium falciparum