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Literature summary for 2.4.2.6 extracted from

  • Pistotnik, E.; Sakamoto, H.; Pochet, S.; Namane, A.; Barzu, O.
    Assay of nucleoside 2-deoxyribosyltransferase activity with pyruvate kinase/lactate dehydrogenase coupling system (1999), Anal. Biochem., 271, 192-193.
    View publication on PubMed
Search for more literature for 2.4.2.6

Application

Application Comment Organism
medicine the low substrate specificity of the enzyme is used advantageously for synthesis of nucleoside analogs, some of them of medical interest Lactobacillus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Lactobacillus sp. the enzyme participates in the nucleoside salvage pathway ?
-
 ?

Organism

Organism UniProt Comment Textmining
Lactobacillus sp.
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 method for determining enzyme activity by coupling the release of adenine from deoxyadenosine to the reaction catalyzed by pyruvate kinase/lactate dehydrogenase via adenine phosphoribosyltransferase and adenylate kinase Lactobacillus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dAMP + 2,6-dichloropurine
-
 Lactobacillus sp. adenine + 2,6-dichloropurin-9-yl-2'-deoxy-beta-D-ribose 5'-phosphate
-
 ?
deoxyadenosine + 2-amino 6-methylmercaptopurine
-
 Lactobacillus sp. adenine + 9-(2-deoxy-beta-D-ribofuranosyl)-2-amino-6-methylmercaptopurine
-
 ?
deoxyadenosine + 2-amino-6-hydroxy 8-mercaptopurine
-
 Lactobacillus sp. adenine + ?
-
 ?
deoxyadenosine + 2-aminobenzimidazole
-
 Lactobacillus sp. adenine + ?
-
 ?
deoxyadenosine + 2-hydroxybenzimidazole
-
 Lactobacillus sp. adenine + ?
-
 ?
deoxyadenosine + 2-thiouracil
-
 Lactobacillus sp. adenine + deoxy-2-thiouridine
-
 ?
deoxyadenosine + 4-amino-5-imidazole carboxamide
-
 Lactobacillus sp. adenine + ?
-
 ?
deoxyadenosine + 5-fluorouracil
-
 Lactobacillus sp. adenine + deoxy-5-fluorouridine
-
 ?
deoxyadenosine + 5-iodouracil
-
 Lactobacillus sp. adenine + deoxy-5-iodouridine
-
 ?
deoxyadenosine + 6-azathymine
-
 Lactobacillus sp. adenine + deoxy-6-deazathymidine
-
 ?
deoxyadenosine + 6-chloroguanine
-
 Lactobacillus sp. adenine + 2'-deoxy-6-chloroguanosine
-
 ?
deoxyadenosine + 6-chloropurine
-
 Lactobacillus sp. adenine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-chloropurine
-
 ?
deoxyadenosine + 6-dimethylaminopurine
-
 Lactobacillus sp. adenine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-dimethylaminopurine
-
 ?
deoxyadenosine + 6-methylpurine
-
 Lactobacillus sp. adenine + 9-(2-deoxy-beta-D-ribofuranosyl)-6-methylpurine
-
 ?
deoxyadenosine + ethyl 4-amino-1H-imidazole-5-carboxylate
-
 Lactobacillus sp. adenine + ethyl 4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-1H-imidazole-5-carboxylate
-
 ?
additional information the enzyme participates in the nucleoside salvage pathway Lactobacillus sp. ?
-
 ?