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Literature summary for 2.4.2.6 extracted from
- Deoxyribosyl transfer catalysis with trans-N-deoxyribosylase. Kinetic study of purine(pyrimidine) to pyrimidine(purine) trans-N-deoxyribosylase (1976), Eur. J. Biochem., 62, 365-372.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenine | - |
Lactobacillus helveticus |  |
| cytosine | - |
Lactobacillus helveticus | |
| deoxyadenosine | linear competitive inhibition of deoxycytidine | Lactobacillus helveticus | |
| deoxycytidine | - |
Lactobacillus helveticus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0073 | - |
adenine | reaction with deoxyinosine | Lactobacillus helveticus | |
| 0.008 | - |
adenine | reaction with deoxyguanosine | Lactobacillus helveticus | |
| 0.019 | - |
adenine | reaction with deoxycytidine | Lactobacillus helveticus | |
| 0.021 | - |
adenine | reaction with deoxyadenosine | Lactobacillus helveticus | |
| 0.073 | - |
cytosine | reaction with deoxyinosine | Lactobacillus helveticus | |
| 0.077 | - |
cytosine | reaction with deoxyguanosine | Lactobacillus helveticus | |
| 0.09 | - |
deoxycytidine | reaction with adenine | Lactobacillus helveticus | |
| 0.092 | - |
deoxyadenosine | reaction with adenine | Lactobacillus helveticus | |
| 0.095 | - |
deoxycytidine | reaction with cytosine | Lactobacillus helveticus | |
| 0.12 | - |
deoxyadenosine | reaction with cytosine | Lactobacillus helveticus | |
| 0.17 | - |
cytosine | reaction with deoxycytidine | Lactobacillus helveticus | |
| 0.22 | - |
cytosine | reaction with deoxyadenosine | Lactobacillus helveticus | |
| 0.346 | - |
deoxyguanosine | reaction with adenine | Lactobacillus helveticus | |
| 0.37 | - |
deoxyguanosine | reaction with cytosine | Lactobacillus helveticus | |
| 3.4 | - |
deoxyinosine | reaction with adenine | Lactobacillus helveticus | |
| 3.5 | - |
deoxyinosine | reaction with cytosine | Lactobacillus helveticus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lactobacillus helveticus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1 | ping-pong bi bi mechanism | Lactobacillus helveticus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.8 | - |
reaction with deoxyinosine and adenine | Lactobacillus helveticus |
| 7.75 | - |
reaction with thymidine and cytosine | Lactobacillus helveticus |
| 43 | - |
reaction with deoxycytidine and adenine | Lactobacillus helveticus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxyadenosine + adenine | - |
Lactobacillus helveticus | adenine + deoxyadenosine | - |
? | |
| deoxyadenosine + cytosine | - |
Lactobacillus helveticus | adenine + deoxycytidine | - |
r | |
| deoxycytidine + adenine | - |
Lactobacillus helveticus | cytosine + deoxyadenosine | - |
r | |
| deoxyguanosine + adenine | - |
Lactobacillus helveticus | guanine + deoxyadenosine | - |
? | |
| deoxyguanosine + cytosine | - |
Lactobacillus helveticus | guanine + deoxycytidine | - |
r | |
| deoxyinosine + adenine | - |
Lactobacillus helveticus | hypoxanthine + deoxyadenosine | - |
r | |
| deoxyinosine + cytosine | - |
Lactobacillus helveticus | hypoxanthine + deoxycytidine | - |
? | |
| thymidine + cytosine | - |
Lactobacillus helveticus | thymine + 2'-deoxycytidine | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
adenine | - |
Lactobacillus helveticus | |
| 0.092 | - |
deoxyadenosine | - |
Lactobacillus helveticus | |
| 0.095 | - |
deoxycytidine | - |
Lactobacillus helveticus | |
| 0.17 | - |
cytosine | - |
Lactobacillus helveticus | |
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