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Literature summary for 2.4.2.6 extracted from
- Nucleoside deoxyribosyltransferase from Lactobacillus helveticus (1978), Methods Enzymol., 51, 446-455.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenine | - |
Lactobacillus helveticus |  |
| cytosine | - |
Lactobacillus helveticus | |
| deoxyadenosine | - |
Lactobacillus helveticus | |
| deoxycytidine | - |
Lactobacillus helveticus | |
| deoxyinosine | - |
Lactobacillus helveticus | |
| hypoxanthine | - |
Lactobacillus helveticus | |
| Tris | complete inhibition of deoxyribosyltransferase I at 0.1 M, pH 6.9. 62% inhibition of nucleoside deoxyribosyltransferase I at 0.8 M, pH 5.9 | Lactobacillus helveticus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.019 | - |
adenine | reaction with deoxycytidine | Lactobacillus helveticus | |
| 0.041 | - |
deoxyinosine | - |
Lactobacillus helveticus | |
| 0.086 | - |
hypoxanthine | - |
Lactobacillus helveticus | |
| 0.09 | - |
deoxycytidine | - |
Lactobacillus helveticus | |
| 0.12 | - |
deoxyadenosine | - |
Lactobacillus helveticus | |
| 0.22 | - |
cytosine | - |
Lactobacillus helveticus | |
| 0.35 | - |
deoxyinosine | - |
Lactobacillus helveticus | |
| 0.45 | - |
deoxyadenosine | - |
Lactobacillus helveticus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 86000 | - |
- |
Lactobacillus helveticus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lactobacillus helveticus | - |
nucleoside deoxyribosyltransferase-I and nucleoside deoxyribosyltransferase-I | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1 | ping-pong bi bi mechanism | Lactobacillus helveticus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5'-fluoro-5'-thymidine + adenine | deoxyribosyltransferase II | Lactobacillus helveticus | 5'-fluoro-5'-deoxythymine + adenosine | - |
? | |
| deoxycytidine + adenine | - |
Lactobacillus helveticus | cytosine + deoxyadenosine | - |
r | |
| deoxyinosine + adenine | - |
Lactobacillus helveticus | hypoxanthine + deoxyadenosine | - |
r | |
| additional information | nucleoside deoxyribosyltransferase I is strictly specific for transfer between purine bases. Nucleoside deoxyribosyltransferase II catalyzes the transfer of the deoxyribosyl moiety between purines or pyrimidines as well as from a purine to a pyrimidine | Lactobacillus helveticus | ? | - |
? | |
| thymidine + xanthine | - |
Lactobacillus helveticus | 9-deoxyribosylxanthine + 7-deoxyribosylxanthine | 20% 9-deoxyribosylxanthine + 80% 7-deoxyribosylxanthine | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| nucleoside deoxyribosyltransferase I | purine nucleoside:purine deoxyribosyltransferase:strictly specific for transfer between purine bases | Lactobacillus helveticus |
| nucleoside deoxyribosyltransferase II | purine(pyrimidine) nucleoside:purine(pyrimidine) deoxyribosyltransferase:catalyzes the transfer of the deoxyribosyl moiety between purines or pyrimidines as well as from a purine to a pyrimidine | Lactobacillus helveticus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.8 | - |
- |
Lactobacillus helveticus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
optimal stability | Lactobacillus helveticus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.021 | - |
adenine | - |
Lactobacillus helveticus | |
| 0.039 | - |
adenine | - |
Lactobacillus helveticus | |
| 0.079 | - |
hypoxanthine | - |
Lactobacillus helveticus | |
| 0.092 | - |
deoxyadenosine | - |
Lactobacillus helveticus | |
| 0.095 | - |
deoxycytidine | - |
Lactobacillus helveticus | |
| 0.17 | - |
cytosine | - |
Lactobacillus helveticus | |
| 0.34 | - |
deoxyinosine | - |
Lactobacillus helveticus | |
| 0.43 | - |
deoxyadenosine | - |
Lactobacillus helveticus | |
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