Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.4 extracted from

  • Yue, H.; Tanaka, K.; Furukawa, T.; Karnik, S.S.; Li, W.
    Thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3 (2012), Biochim. Biophys. Acta, 1823, 1316-1323.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.4

Cloned(Commentary)

Cloned (Comment) Organism
expression in rat vascular smooth muscle cell Homo sapiens

Protein Variants

Protein Variants Comment Organism
K115E loss of enzymic activity. Expression of mutant in rat vascular smooth muscle cell does not have significant effect on cell proliferation Homo sapiens
L148R loss of enzymic activity. Expression of mutant in rat vascular smooth muscle cell does not have significant effect on cell proliferation Homo sapiens
R202S loss of enzymic activity. Expression of mutant in rat vascular smooth muscle cell does not have significant effect on cell proliferation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

General Information

General Information Comment Organism
physiological function thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3. Overexpression of thymidine phosphorylase increases STAT3 phosphorylation and expression in vascular smooth muscle cells via Lyn. STAT3 protein but not STAT3 phosphorylation is necessary for thymidine phosphorylase inhibited vascular smooth muscle cell proliferation Homo sapiens