Cloned (Comment) | Organism |
---|---|
expression in rat vascular smooth muscle cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
K115E | loss of enzymic activity. Expression of mutant in rat vascular smooth muscle cell does not have significant effect on cell proliferation | Homo sapiens |
L148R | loss of enzymic activity. Expression of mutant in rat vascular smooth muscle cell does not have significant effect on cell proliferation | Homo sapiens |
R202S | loss of enzymic activity. Expression of mutant in rat vascular smooth muscle cell does not have significant effect on cell proliferation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
General Information | Comment | Organism |
---|---|---|
physiological function | thymidine phosphorylase inhibits vascular smooth muscle cell proliferation via upregulation of STAT3. Overexpression of thymidine phosphorylase increases STAT3 phosphorylation and expression in vascular smooth muscle cells via Lyn. STAT3 protein but not STAT3 phosphorylation is necessary for thymidine phosphorylase inhibited vascular smooth muscle cell proliferation | Homo sapiens |