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Literature summary for 2.4.2.4 extracted from

  • Hatano, A.; Harano, A.; Takigawa, Y.; Naramoto, Y.; Toda, K.; Nakagomi, Y.; Yamada, H.
    Kinetic parameters and recognition of thymidine analogues with varying functional groups by thymidine phosphorylase (2008), Bioorg. Med. Chem., 16, 3866-3870.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
5-chloro-6-[1-(2-iminopyrrolidinyl)methyl]uracil hydrochloride
-
Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5
-
thymidine in 50 mM phosphate buffer, pH 6.8 Escherichia coli
10
-
3'-Deoxythymidine in 50 mM phosphate buffer, pH 6.8 Escherichia coli
32
-
5'-Deoxythymidine in 50 mM phosphate buffer, pH 6.8 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione + phosphate 56% conversion after one h Escherichia coli ?
-
?
1-[(2R,4S,5R)-5-(aminomethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate 11% conversion after one h Escherichia coli ?
-
?
1-[(2R,4S,5R)-5-(hydroxymethyl)-4-sulfanyltetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate 0.76% conversion after one h Escherichia coli ?
-
?
1-[(2R,4S,5S)-4-hydroxy-5-(sulfanylmethyl)tetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate 39% conversion after one h Escherichia coli ?
-
?
1-[(2R,4S,5S)-5-(chloromethyl)-4-hydroxytetrahydrofuran-2-yl]-5-methylpyrimidine-2,4(1H,3H)-dione + phosphate 24% conversion after one h Escherichia coli ?
-
?
3'-deoxythymidine + phosphate 3.2% conversion after one h Escherichia coli thymine + 2,3-dideoxy-D-ribose 1-phosphate
-
?
3'-thiothymidine + phosphate 0.76% conversion after 1 h Escherichia coli thymine + 3-thio-2,3-dideoxy-D-ribose 1-phosphate
-
?
4'-thiothymidine + phosphate 3.8% conversion after one h Escherichia coli ?
-
?
5'-amino-5'-deoxythymidine + phosphate 11% conversion after 1 h Escherichia coli thymine + 5-amino-2,5-dideoxy-D-ribose 1-phosphate
-
?
5'-chloro-5'-deoxythymidine + phosphate 24% conversion after 1 h Escherichia coli thymine + 5-chloro-2,5-dideoxy-D-ribose 1-phosphate
-
?
5'-deoxythymidine + phosphate 68% conversion after one h Escherichia coli thymine + 2,5-dideoxy-D-ribose 1-phosphate
-
?
5'-thiothymidine + phosphate 39% conversion after 1 h Escherichia coli thymine + 5-thio-2,5-dideoxy-D-ribose 1-phosphate
-
?
6-azathymidine + phosphate 5.4% conversion after one h Escherichia coli uracil + deoxyribose-1-phosphate
-
?
additional information no activity with 3'beta-thymidine, 4'-thio-1'-alpha-thymidine, 1-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]thymine, 5-methyl-2-pyrimidinone nucleoside, and deoxycytidine Escherichia coli ?
-
?
thymidine + phosphate 86% conversion after one h Escherichia coli thymine + 2-deoxy-D-ribose 1-phosphate
-
?
uracil + phosphate 88% conversion after one h Escherichia coli uracil + ribose 1-phosphate
-
?
uridine + phosphate 56% conversion after 1 h Escherichia coli uracil + D-ribose 1-phosphate
-
?