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Literature summary for 2.4.2.4 extracted from

  • Ikeda, R.; Tajitsu, Y.; Iwashita, K.; Che, X.F.; Yoshida, K.; Ushiyama, M.; Furukawa, T.; Komatsu, M.; Yamaguchi, T.; Shibayama, Y.; Yamamoto, M.; Zhao, H.Y.; Arima, J.; Takeda, Y.; Akiyama, S.; Yamada, K.
    Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3 (2008), Biochem. Biophys. Res. Commun., 370, 220-224.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Jurkat cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information thymidine phosphorylase and its degradation product 2-deoxy-D-ribose suppress hypoxia-induced apoptosis, the upregulation of hypoxia-inducible factor 1alpha and the proapoptotic factor, BNIP3, and caspase 3 activation induced by hypoxia Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymidine + phosphate
-
Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
r