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Literature summary for 2.4.2.4 extracted from

  • Mendieta, J.; Martin-Santamaria, S.; Priego, E.M.; Balzarini, J.; Camarasa, M.J.; Perez-Perez, M.J.; Gago, F.
    Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations (2004), Biochemistry, 43, 405-414.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Escherichia coli P07650
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxythymidine + phosphate
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Escherichia coli thymine + 2-deoxy-D-ribose 1-phosphate
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?
thymidine + phosphate SN1 mechanism for the phosphorolysis reaction, relevant interaction between the His85 imidazole ring and the O2 of thymidine suggesting that this highly conserved residue could play an important role in the catalytic mechanism of TPase Escherichia coli thymine + 2-deoxy-D-ribose 1-phosphate
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?

Synonyms

Synonyms Comment Organism
Tpase
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Escherichia coli