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Literature summary for 2.4.2.4 extracted from

  • Klein, R.S.; Lenzi, M.; Lim, T.H.; Hotchkiss, K.A.; Wilson, P.; Schwartz, E.L.
    Novel 6-substituted uracil analogs as inhibitors of the angiogenic actions of thymidine phosphorylase (2001), Biochem. Pharmacol., 62, 1257-1263.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6-(2-aminoethyl)amine-5-chlorouracil AEAC Homo sapiens
additional information 5- and 6-substituted uracil analogs Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens angiogenic activity ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information angiogenic activity Homo sapiens ?
-
?
thymidine + phosphate
-
Homo sapiens thymine + 2-deoxy-D-ribose 1-phosphate
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000165
-
6-(2-aminoethyl)amine-5-chlorouracil
-
Homo sapiens