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Literature summary for 2.4.2.38 extracted from

  • Strasser, R.; Stadlmann, J.; Schaehs, M.; Stiegler, G.; Quendler, H.; Mach, L.; Gloessl, J.; Weterings, K.; Pabst, M.; Steinkellner, H.
    Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure (2008), Plant Biotechnol. J., 6, 392-402.
    View publication on PubMed
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Application

Application Comment Organism
biotechnology glycoengineering: humanized N-glycosylation in plants by knock-down of plant-specific N-glycan maturation enzymes, pharmaceutical glycoprotein production in plant Nicotiana benthamiana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Nicotiana benthamiana
-
 ? strongly reduced biosynthesis of beta 1,2-xylose-containing glycoepitopes upon knock-down of endogenous beta 1,2-xylosyltransferase using RNA interference approaches ?

Organism

Organism UniProt Comment Textmining
Nicotiana benthamiana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 Nicotiana benthamiana ? strongly reduced biosynthesis of beta 1,2-xylose-containing glycoepitopes upon knock-down of endogenous beta 1,2-xylosyltransferase using RNA interference approaches ?
additional information
-
 Nicotiana benthamiana ? human anti HIV monoclonal antibody 2G12 produced in absence of endogenous beta 1,2-xylosyltransferase (knock-down by RNA interference) is functional but contains N-glycan species lacking beta 1,2-xylose residues corresponding to authentic human N-glycosylation ?

Synonyms

Synonyms Comment Organism
beta 1,2-xylosyltransferase
-
 Nicotiana benthamiana
XylT
-
 Nicotiana benthamiana