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Literature summary for 2.4.2.36 extracted from

  • Zhang, Y.; Liu, S.; Lajoie, G.; Merrill, A.R.
    The role of the diphthamide-containing loop within eukaryotic elongation factor 2 in ADP-ribosylation by Pseudomonas aeruginosa exotoxin A (2008), Biochem. J., 413, 163-174.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of the catalytic fragment of ExoA, ExoAc Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
eEF2 + NAD+ Pseudomonas aeruginosa i.e. eukaryotic elongation factor 2, contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of Pseudomonas aeruginosa exotoxin A eEF2 N-(ADP-D-ribosyl)diphthamide + NADH + H+
-
?
NAD+ + peptide diphthamide Pseudomonas aeruginosa
-
nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant catalytic fragment of ExoA, ExoAc Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
eEF2 + NAD+ i.e. eukaryotic elongation factor 2, contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of Pseudomonas aeruginosa exotoxin A Pseudomonas aeruginosa eEF2 N-(ADP-D-ribosyl)diphthamide + NADH + H+
-
?
eEF2 + NAD+ i.e. eukaryotic elongation factor 2 with a diphthamide-containing loop comprising residues Leu693-Gly703, ADP-ribosylation at His699, site determination by mass spectrometry and mutational analysis, overview Pseudomonas aeruginosa eEF2 N-(ADP-D-ribosyl)diphthamide + NADH + H+
-
?
NAD+ + peptide diphthamide
-
Pseudomonas aeruginosa nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide
-
?

Synonyms

Synonyms Comment Organism
ExoA
-
Pseudomonas aeruginosa
exotoxin A
-
Pseudomonas aeruginosa

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Pseudomonas aeruginosa