Cloned (Comment) | Organism |
---|---|
overexpression of the catalytic fragment of ExoA, ExoAc | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
eEF2 + NAD+ | Pseudomonas aeruginosa | i.e. eukaryotic elongation factor 2, contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of Pseudomonas aeruginosa exotoxin A | eEF2 N-(ADP-D-ribosyl)diphthamide + NADH + H+ | - |
? | |
NAD+ + peptide diphthamide | Pseudomonas aeruginosa | - |
nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
recombinant catalytic fragment of ExoA, ExoAc | Pseudomonas aeruginosa |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
eEF2 + NAD+ | i.e. eukaryotic elongation factor 2, contains a post-translationally modified histidine residue, known as diphthamide, which is the specific ADP-ribosylation target of Pseudomonas aeruginosa exotoxin A | Pseudomonas aeruginosa | eEF2 N-(ADP-D-ribosyl)diphthamide + NADH + H+ | - |
? | |
eEF2 + NAD+ | i.e. eukaryotic elongation factor 2 with a diphthamide-containing loop comprising residues Leu693-Gly703, ADP-ribosylation at His699, site determination by mass spectrometry and mutational analysis, overview | Pseudomonas aeruginosa | eEF2 N-(ADP-D-ribosyl)diphthamide + NADH + H+ | - |
? | |
NAD+ + peptide diphthamide | - |
Pseudomonas aeruginosa | nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ExoA | - |
Pseudomonas aeruginosa |
exotoxin A | - |
Pseudomonas aeruginosa |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Pseudomonas aeruginosa |