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Literature summary for 2.4.2.31 extracted from

  • Friedrich, M.; Boehlig, L.; Kirschner, R.D.; Engeland, K.; Hauschildt, S.
    Identification of two regulatory binding sites which confer myotube specific expression of the mono-ADP-ribosyltransferase ART1 gene (2008), BMC Mol. Biol., 9, 91.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
mutated amplification products transformed into the Escherichia coli DH 5alpha strain. HEK 293-T cells stably transfected with ART1 or ART3 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
C2C12 cell ART1, ART3 and ART5 present in myotubes, absent, with the exception of ART3, from myoblasts Mus musculus
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C3H10T1/2 cell ART1, ART3 and ART5 present in myotubes. Absent from mesenchymal progenitor cells and, with the exception of ART3, in myoblasts Mus musculus
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skeletal muscle cell
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information among the three ARTs being expressed at the myotube stage ADP-ribosylation of surface proteins can only be attributed to ART1 Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
ART1
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Mus musculus
ART3
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Mus musculus
ART5
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Mus musculus
mono-ADP-ribosyltransferase
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Mus musculus

Expression

Organism Comment Expression
Mus musculus mutating the DNA consensus sequence of either the E box or the A/T-rich element results in a nearly complete loss of ART1 promoter inducibility down
Mus musculus expression of ART1, ART3 and ART5 mRNA in myogenic cell lines during skeletal muscle differentiation in vitro. ART1 expression is restricted to myotube formation. ART5 similar to ART1 mRNA is strongly upregulated during muscle cell differentiation. Upregulation of ART3 mRNA only in C3H10T1/2 cells. Differentiation-dependent upregulation of ART1 mRNA is induced by the binding of myogenin to an E box and of MEF-2 to an A/T-rich element in the proximal promoter region of the ART1 gene up