Crystallization (Comment) | Organism |
---|---|
in complex with inhibitors, sitting drop vapor diffusion method | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2S)-2-[[3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoyl]amino]-3-phenylpropanamide | - |
Homo sapiens | |
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1R)-1-(pyridin-2-yl)ethyl]propanamide | - |
Homo sapiens | |
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1R)-1-phenylethyl]propanamide | - |
Homo sapiens | |
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-(pyridin-2-yl)ethyl]propanamide | - |
Homo sapiens | |
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-phenylethyl]propanamide | - |
Homo sapiens | |
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-phenylpropyl]propanamide | - |
Homo sapiens | |
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(4-sulfamoylphenyl)ethyl]propanamide | - |
Homo sapiens | |
3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(pyridin-2-yl)ethyl]propanamide | - |
Homo sapiens | |
methyl (2S)-2-[[3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoyl]amino]-3-phenylpropanoate | - |
Homo sapiens | |
N-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | - |
Homo sapiens | |
N-[(1S)-2,3-dihydro-1H-inden-1-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | - |
Homo sapiens | |
N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | - |
Homo sapiens | |
N-[(2S)-1-hydroxybutan-2-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | - |
Homo sapiens | |
N-[(2S)-1-hydroxypropan-2-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | - |
Homo sapiens | |
N-[1-[4-(1H-imidazol-1-yl)phenyl]ethyl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (ADP-D-ribosyl)n-acceptor | Homo sapiens | - |
nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y6F1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (ADP-D-ribosyl)n-acceptor | - |
Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADP-ribosyltransferase | - |
Homo sapiens |
ADP-ribosyltransferase 3 | - |
Homo sapiens |
ARTD3 | - |
Homo sapiens |
PARP3 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0009 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-phenylethyl]propanamide | |
0.001 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | |
0.0013 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-(pyridin-2-yl)ethyl]propanamide | |
0.0022 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1S)-1-phenylpropyl]propanamide | |
0.0022 | - |
pH and temperature not specified in the publication | Homo sapiens | methyl (2S)-2-[[3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoyl]amino]-3-phenylpropanoate | |
0.0038 | - |
pH and temperature not specified in the publication | Homo sapiens | (2S)-2-[[3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanoyl]amino]-3-phenylpropanamide | |
0.0096 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[(2S)-1-hydroxybutan-2-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | |
0.0111 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[(2S)-1-hydroxypropan-2-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | |
0.0132 | - |
pH and temperature not specified in the publication | Homo sapiens | N-[1-[4-(1H-imidazol-1-yl)phenyl]ethyl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | |
0.0144 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(4-sulfamoylphenyl)ethyl]propanamide | |
0.0152 | - |
pH and temperature not specified in the publication | Homo sapiens | 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1R)-1-phenylethyl]propanamide | |
0.1 | - |
IC50 above 0.1 mM, pH and temperature not specified in the publication | Homo sapiens | 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[(1R)-1-(pyridin-2-yl)ethyl]propanamide | |
0.1 | - |
IC50 above 0.1 mM, pH and temperature not specified in the publication | Homo sapiens | N-[(1R)-2,3-dihydro-1H-inden-1-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide | |
0.1 | - |
IC50 above 0.1 mM, pH and temperature not specified in the publication | Homo sapiens | N-[(1S)-2,3-dihydro-1H-inden-1-yl]-3-(4-oxo-3,4-dihydroquinazolin-2-yl)propanamide |