Cloned (Comment) | Organism |
---|---|
expressed in Mus musculus | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nuclear envelope | - |
Homo sapiens | 5635 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme has the ability to ADP-ribosylate itself | ? | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | Homo sapiens | - |
nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme has the ability to ADP-ribosylate itself | Homo sapiens | ? | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | - |
Homo sapiens | nicotinamide + (ADP-D-ribosyl)n+1-acceptor + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADP-ribosyltransferase | - |
Homo sapiens |
ARTD11 | - |
Homo sapiens |
mono(ADP-ribosyl) transferase | - |
Homo sapiens |
PARP11 | - |
Homo sapiens |
poly(ADP-ribose) polymerase-11 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme deletion results in teratozoospermia and male infertility in mice due to the formation of abnormally shaped fertilization-incompetent sperm, despite normal testis weights and sperm counts | Homo sapiens |
physiological function | the enzyme displays functional relevance for nuclear envelope stability and nuclear reorganization during spermiogenesis and is important for proper sperm head shaping | Homo sapiens |