Activating Compound | Comment | Organism | Structure |
---|---|---|---|
3-amino-1-methyl-5H-pyrido[4,3-b]indole | i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole | i.e. Trp-P-1, 94% inhibition at 5 mM, IC50: 0.22 mM | Bos taurus | |
3-amino-1-methyl-5H-pyrido[4,3-b]indole | i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM | Bos taurus | |
additional information | comparison of the effects of heterocyclic amines acting as potent carcinogens on PARP-1 and the arginine-specific mono-ADP-ribosyltransferase A, MART-A, EC 2.4.2.31, overview | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (ADP-D-ribosyl)n-acceptor | Bos taurus | the enzyme is a DNA repair enzyme | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
thymus | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (ADP-D-ribosyl)n-acceptor | the enzyme is a DNA repair enzyme | Bos taurus | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + histone H2B | - |
Bos taurus | nicotinamide + (ADP-D-ribosyl)-histone H2B | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PARP-1 | - |
Bos taurus |
poly(ADP-ribose) polymerase-1 | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.22 | - |
i.e. Trp-P-1, 94% inhibition at 5 mM, IC50: 0.22 mM | Bos taurus | 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole | |
2.2 | - |
i.e. Trp-P-2, 34% activation at 1 mM, 7% inhibition at 5 mM, IC50: 2.2 mM | Bos taurus | 3-amino-1-methyl-5H-pyrido[4,3-b]indole |