Cloned (Comment) | Organism |
---|---|
trancriptional regulation, overview | Drosophila melanogaster |
trancriptional regulation, overview | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | phenotypes of isozyme-deficient mutant mice, overview | Drosophila melanogaster |
additional information | phenotypes of isozyme-deficient mutant mice, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Drosophila melanogaster | 5634 | - |
nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Drosophila melanogaster | transcriptional regulation mechanism, overview | ? | - |
? | |
additional information | Mus musculus | transcriptional regulation mechanism, overview | ? | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | Drosophila melanogaster | poly(ADP-ribosyl)ation, i.e. PARylation, plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1, physiologic functions, detailed overview, synthesis and degradation of PAR on an acceptor protein, pathway overview, the enzyme is involved in regulation of the steady-state levels of PAR | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | Mus musculus | poly(ADP-ribosyl)ation, i.e. PARylation, plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1, physiologic functions, detailed overview, synthesis and degradation of PAR on an acceptor protein, pathway overview, the enzyme is involved in regulation of the steady-state levels of PAR | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Mus musculus | - |
isozymes PARP-1 and PARP-2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | transcriptional regulation mechanism, overview | Drosophila melanogaster | ? | - |
? | |
additional information | transcriptional regulation mechanism, overview | Mus musculus | ? | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation, i.e. PARylation, plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1, physiologic functions, detailed overview, synthesis and degradation of PAR on an acceptor protein, pathway overview, the enzyme is involved in regulation of the steady-state levels of PAR | Drosophila melanogaster | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | poly(ADP-ribosyl)ation, i.e. PARylation, plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1, physiologic functions, detailed overview, synthesis and degradation of PAR on an acceptor protein, pathway overview, the enzyme is involved in regulation of the steady-state levels of PAR | Mus musculus | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | linking a long negatively charged polymer to a protein, PARP catalyzes the polymerization of ADP-ribose units from donor NAD+ molecules on target proteins, resulting in the attachment of PAR, each residue in PAR contains an adenine moiety capable of base stacking and hydrogen bonding, as well as two phosphate groups that carry negative charges, substrate structure, overview | Drosophila melanogaster | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? | |
NAD+ + (ADP-D-ribosyl)n-acceptor | linking a long negatively charged polymer to a protein, PARP-1 catalyzes the polymerization of ADP-ribose units from donor NAD+ molecules on target proteins, resulting in the attachment of PAR, each residue in PAR contains an adenine moiety capable of base stacking and hydrogen bonding, as well as two phosphate groups that carry negative charges, substrate structure, overview | Mus musculus | nicotinamide + (ADP-D-ribosyl)n+1-acceptor | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | structural and functional organizations of PARP-1 and PARP-2, overview | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
PAR polymerase | - |
Drosophila melanogaster |
PAR polymerase | - |
Mus musculus |
PARP | - |
Drosophila melanogaster |
PARP | - |
Mus musculus |