Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of an enzyme-deficient strain 388DELTAexoS | Pseudomonas aeruginosa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + cyclophilin A | Pseudomonas aeruginosa | cytosolic protein of several human epithelial cells, modification at Arg55 and Arg69 of cyclophilin A, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, overview | nicotinamide + (ADP-D-ribosyl)-cyclophilin A | - |
? | |
NAD+ + cyclophilin A | Pseudomonas aeruginosa 388 | cytosolic protein of several human epithelial cells, modification at Arg55 and Arg69 of cyclophilin A, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, overview | nicotinamide + (ADP-D-ribosyl)-cyclophilin A | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Pseudomonas aeruginosa | - |
- |
- |
Pseudomonas aeruginosa 388 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | exoenzyme S is a bifunctional type III secretion, TTS, effector protein, with GTPase-activating and ADP-ribosyltransferase activities | Pseudomonas aeruginosa | ? | - |
? | |
additional information | exoenzyme S is a bifunctional type III secretion, TTS, effector protein, with GTPase-activating and ADP-ribosyltransferase activities | Pseudomonas aeruginosa 388 | ? | - |
? | |
NAD+ + cyclophilin A | cytosolic protein of several human epithelial cells, modification at Arg55 and Arg69 of cyclophilin A, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, overview | Pseudomonas aeruginosa | nicotinamide + (ADP-D-ribosyl)-cyclophilin A | - |
? | |
NAD+ + cyclophilin A | a non-G-protein substrate with peptidyl-prolyl isomerase activity, from several human epithelial cells, modification at Arg55 and Arg69, but not at Arg148, of cyclophilin A, i.e. CpA, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, activity with CpA mutants, overview | Pseudomonas aeruginosa | nicotinamide + (ADP-D-ribosyl)-cyclophilin A | - |
? | |
NAD+ + cyclophilin A | cytosolic protein of several human epithelial cells, modification at Arg55 and Arg69 of cyclophilin A, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, overview | Pseudomonas aeruginosa 388 | nicotinamide + (ADP-D-ribosyl)-cyclophilin A | - |
? | |
NAD+ + cyclophilin A | a non-G-protein substrate with peptidyl-prolyl isomerase activity, from several human epithelial cells, modification at Arg55 and Arg69, but not at Arg148, of cyclophilin A, i.e. CpA, ADP-ribosylation of CpA efficiently inhibits CpA binding to calcineurin/PP2B phosphatase, activity with CpA mutants, overview | Pseudomonas aeruginosa 388 | nicotinamide + (ADP-D-ribosyl)-cyclophilin A | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADP-ribosyltransferase | - |
Pseudomonas aeruginosa |
ADPRT | - |
Pseudomonas aeruginosa |
exoenzyme S | - |
Pseudomonas aeruginosa |
ExoS | - |
Pseudomonas aeruginosa |
TTS-ExoS | - |
Pseudomonas aeruginosa |