Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | PARP-1 is activated in response to DNA damage and participates in DNA repair, genomic integrity and cell death | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockout mice show increased inflammatory response in PARP-1 -/- compared to wild-type animals, characterized by neutrophil infiltration and increased IL-6 levels in broncho-alveolar lavages, the lesions are reversible, since the extent of the hyperplastic regions is reduced after 21 days of recovery and do not result in fibrosis, phenotype, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
PJ34 | potent PARP inhibitor | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview | ? | - |
? | |
additional information | Mus musculus Sv129 | PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
Sv129 mice | - |
Mus musculus Sv129 | - |
Sv129 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epithelial cell | - |
Mus musculus | - |
fibroblast | primary, from lung | Mus musculus | - |
lung | PARP-1 in lung repair during recovery after hyperoxia, that is induced by 5-bromo-2-deoxyuridine, overview | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview | Mus musculus | ? | - |
? | |
additional information | PARP-1 plays an essential role in the control of cell repair and tissue remodeling after hyperoxia-induced lung injury, overview | Mus musculus Sv129 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PARP-1 | - |
Mus musculus |
poly(ADP-ribose) polymerase-1 | - |
Mus musculus |