Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.30 extracted from

  • Barbieri, J.T.; Sun, J.
    Pseudomonas aeruginosa ExoS and ExoT (2004), Rev. Physiol. Biochem. Pharmacol., 152, 79-92.
    View publication on PubMed
Search for more literature for 2.4.2.30

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane localization domain Pseudomonas aeruginosa 16020
-

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
 ExoS
-
Pseudomonas aeruginosa
-
 ExoT
-
Pseudomonas aeruginosa ExoS
-
 ExoS
-
Pseudomonas aeruginosa ExoT
-
 ExoT
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor ExoS has polysubstrate specificity and can ADP-ribosylate numerous host proteins, e.g. monomeric GTPase or vimentin. ExoS also undergoes auto-ADP-ribosylation. Ras has multiple alternative sites for ADP-ribosylation Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor ExoT ADP-ribosylates a restricted subset of host proteins including the Crk proteins Pseudomonas aeruginosa nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor ExoS has polysubstrate specificity and can ADP-ribosylate numerous host proteins, e.g. monomeric GTPase or vimentin. ExoS also undergoes auto-ADP-ribosylation. Ras has multiple alternative sites for ADP-ribosylation Pseudomonas aeruginosa ExoS nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor ExoT ADP-ribosylates a restricted subset of host proteins including the Crk proteins Pseudomonas aeruginosa ExoS nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor ExoS has polysubstrate specificity and can ADP-ribosylate numerous host proteins, e.g. monomeric GTPase or vimentin. ExoS also undergoes auto-ADP-ribosylation. Ras has multiple alternative sites for ADP-ribosylation Pseudomonas aeruginosa ExoT nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
NAD+ + (ADP-D-ribosyl)n-acceptor ExoT ADP-ribosylates a restricted subset of host proteins including the Crk proteins Pseudomonas aeruginosa ExoT nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Synonyms

Synonyms Comment Organism
ExoS bifunctional type-III cytotoxin with an N-terminal RhoGAP domain and and C-terminal ADP-ribosylation domain Pseudomonas aeruginosa
ExoT bifunctional type-III cytotoxin with an N-terminal RhoGAP domain and and C-terminal ADP-ribosylation domain Pseudomonas aeruginosa