Literature summary for 2.4.2.30 extracted from

Liu, S.; Yahr, T.L.; Frank, D.W.; Barbieri, J.T.
Biochemical relationships between the 53-kilodalton (Exo53) and 49-kilodalton (ExoS) forms of exoenzyme S of Pseudomonas aeruginosa (1997), J. Bacteriol., 179, 1609-1613.

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Protein Variants

Protein Variants	Comment	Organism
additional information	the recombinant deletion protein N223-53 which contains the catalytic domain of Exo53, comprising its 223 carboxyl-terminal residues catalyzes the FAS-dependent ADP-ribosylation of soybean trypsin inhibitor at 0.4% and of the Ras protein at 1.0% of the rates of catalysis by N222-49 (a protein comprising the 222 carboxyl-terminal residues of ExoS, which represent its catalytic domain). N223-53 possesesses binding affinities for NAD+ and SBTI similar to those of N222-49 but shows a lower rate for the ADP-ribosylation of SBTI	Pseudomonas aeruginosa
additional information	the recombinant deletion protein N223-53 which contains the catalytic domain of Exo53, comprising its 223 carboxyl-terminal residues catalyzes the FAS-dependent ADP-ribosylation of soybean trypsin inhibitor at 0.4% and of the Ras protein at 1.0% of the rates of catalysis by N222-49 (a protein comprising the 222 carboxyl-terminal residues of ExoS, which represent its catalytic domain). N223-53 possesesses binding affinities for NAD+ and SBTI similar to those of N222-49 but shows a lower velocity rate for the ADP-ribosylation of SBTI	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	Exo53 form of exoenzyme S	-
Pseudomonas aeruginosa	-	ExoS form of exoenzyme S	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + (ADP-D-ribosyl)n-Ras protein	-	Pseudomonas aeruginosa	nicotinamide + (ADP-D-ribosyl)n+1-Ras protein	-	?
NAD+ + (ADP-D-ribosyl)n-soybean trypsin inhibitor	-	Pseudomonas aeruginosa	nicotinamide + (ADP-D-ribosyl)n+1-soybean trypsin inhibitor	-	?

Synonyms

Synonyms	Comment	Organism
Exo53	-	Pseudomonas aeruginosa
exoenzyme S	-	Pseudomonas aeruginosa
ExoS	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)