Literature summary for 2.4.2.30 extracted from

McGuffie, E.M.; Fraylick, J.E.; Hazen-Martin, D.J.; Vincent, T.S.; Olson, J.C.
Differential sensitivity of human epithelial cells to Pseudomonas aeruginosa exoenzyme S (1999), Infect. Immun., 67, 3494-3503.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor	Pseudomonas aeruginosa	exoenzyme S is an ADP-ribosyltransferase produced and directly translocated into eukaryotic cells by the opportunistic pathogen Pseudomonas aeruginosa. Factors expressed by growing epithelial cells are required for the bacterial contact-dependent translocation of ExoS. As normal epithelial cells differentiate into polarized confluent monolayers, expression of these factors is altered, and cells in turn become more resistant to the effects of ExoS	nicotinamide + (ADP-D-ribosyl)n+1-acceptor	-	?

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor	exoenzyme S is an ADP-ribosyltransferase produced and directly translocated into eukaryotic cells by the opportunistic pathogen Pseudomonas aeruginosa. Factors expressed by growing epithelial cells are required for the bacterial contact-dependent translocation of ExoS. As normal epithelial cells differentiate into polarized confluent monolayers, expression of these factors is altered, and cells in turn become more resistant to the effects of ExoS	Pseudomonas aeruginosa	nicotinamide + (ADP-D-ribosyl)n+1-acceptor	-	?

Synonyms

Synonyms	Comment	Organism
exoenzyme S	-	Pseudomonas aeruginosa
ExoS	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)