Literature summary for 2.4.2.30 extracted from

Rankin, P.W.; Jacobson, E.L.; benjamin, R.C.; Moss, J.; Jacobson, M.K.
Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo (1989), J. Biol. Chem., 264, 4312-4317.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-methylnicotinamide chloride	IC50: 1.7 mM	Bos taurus
2-Aminobenzamide	IC50: 0.1 mM	Bos taurus
3-aminobenzamide	IC50: 0.0054	Bos taurus
3-isobutyl-1-methylxanthine	IC50: 3.1 mM	Bos taurus
3-Methoxybenzamide	IC50: 0.0034 mM	Bos taurus
4-Aminobenzamide	IC50: 0.4 mM	Bos taurus
5-bromodeoxyuridine	IC50: 0.015 mM	Bos taurus
5-Methylnicotinamide	IC50: 0.07	Bos taurus
8-Methylnicotinamide	IC50: 7.8 mM	Bos taurus
Benzamide	IC50: 0.0033 mM	Bos taurus
Caffeine	IC50: 1.4 mM	Bos taurus
hypoxanthine	IC50: 1.7 mM	Bos taurus
Isonicotinate hydrazide	IC50: 4.8 MM	Bos taurus
nicotinamide	IC50: 0.031 mM	Bos taurus
Pyrazinamide	IC50: 0.13 mM	Bos taurus
Theobromine	IC50: 0.11 mM	Bos taurus
theophylline	IC50: 0.0046	Bos taurus
thymidine	IC50: 0.043	Bos taurus
Zn2+	ZnCl2, IC50: 0.077 mM	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	calf	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thymus	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + (ADP-D-ribosyl)n-acceptor	-	Bos taurus	nicotinamide + (ADP-D-ribosyl)n+1-acceptor	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0033	-	IC50: 0.0033 mM	Bos taurus	Benzamide
0.0034	-	IC50: 0.0034 mM	Bos taurus	3-Methoxybenzamide
0.0054	-	IC50: 0.0054	Bos taurus	3-aminobenzamide
0.015	-	IC50: 0.015 mM	Bos taurus	5-bromodeoxyuridine
0.031	-	IC50: 0.031 mM	Bos taurus	nicotinamide
0.043	-	IC50: 0.043 mM	Bos taurus	thymidine
0.046	-	IC50: 0.046 mM	Bos taurus	theophylline
0.07	-	IC50: 0.07 mM	Bos taurus	5-Methylnicotinamide
0.077	-	ZnCl2, IC50: 0.077 mM	Bos taurus	Zn2+
0.1	-	IC50: 0.1 mM	Bos taurus	2-Aminobenzamide
0.11	-	IC50: 0.11 mM	Bos taurus	Theobromine
0.13	-	IC50: 0.13 mM	Bos taurus	Pyrazinamide
0.4	-	IC50: 0.4 mM	Bos taurus	4-Aminobenzamide
1.4	-	IC50: 1.4 mM	Bos taurus	Caffeine
1.7	-	IC50: 1.7 mM	Bos taurus	hypoxanthine
1.7	-	IC50: 1.7 mM	Bos taurus	1-methylnicotinamide chloride
3.1	-	IC50: 3.1 mM	Bos taurus	3-isobutyl-1-methylxanthine
4.8	-	IC50: 4.8 mM	Bos taurus	Isonicotinate hydrazide
7.8	-	IC50: 7.8 mM	Bos taurus	8-Methylnicotinamide

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Release 2023.1 (January 2023)