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Literature summary for 2.4.2.30 extracted from

  • Satoh, M.S.; Lindahl, T.
    Role of poly(ADP-ribose) formation in DNA repair (1992), Nature, 356, 356-358.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
DNA enzyme has an N-terminal binding domain Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens role of the enzyme in DNA repair, the unmodified polymerase molecules bind tightly to DNA strand breaks: auto-poly(ADP-ribosyl)ation of the protein then effects its release and allows access to lesions for DNA repair enzymes ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information role of the enzyme in DNA repair, the unmodified polymerase molecules bind tightly to DNA strand breaks: auto-poly(ADP-ribosyl)ation of the protein then effects its release and allows access to lesions for DNA repair enzymes Homo sapiens ?
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?
NAD+ + (ADP-D-ribosyl)n-acceptor auto-poly(ADP-ribosyl)ation Homo sapiens nicotinamide + (ADP-D-ribosyl)n+1-acceptor
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