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Literature summary for 2.4.2.3 extracted from

  • Yan, R.; Wan, L.; Pizzorno, G.; Cao, D.
    Uridine phosphorylase in breast cancer: a new prognostic factor? (2006), Front. Biosci., 11, 2759-2766.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.02
-
alpha-D-ribose-1-phosphate cosubstrate: 5-fluorouracil, enzyme from liver Rattus norvegicus
0.03
-
alpha-D-ribose-1-phosphate cosubstrate: uracil, enzyme from liver Rattus norvegicus
0.036
-
5-fluorouracil cosubstrate: alpha-D-ribose-1-phosphate, enzyme from liver Rattus norvegicus
0.038
-
alpha-D-ribose-1-phosphate cosubstrate: 5-fluorouracil, enzyme from colon tumor Rattus norvegicus
0.04
-
alpha-D-ribose-1-phosphate cosubstrate: 5-fluorouracil, enzyme from colon tumor Rattus norvegicus
0.046
-
5-fluorouracil cosubstrate: alpha-D-ribose-1-phosphate, enzyme from colon tumor Rattus norvegicus
0.06
-
5-fluorouracil cosubstrate: alpha-D-ribose-1-phosphate, enzyme from colon tumor Rattus norvegicus
0.087
-
alpha-D-ribose-1-phosphate cosubstrate: uracil, enzyme from colon tumor Rattus norvegicus
0.367
-
Uracil cosubstrate: alpha-D-ribose-1-phosphate, enzyme from colon tumor Rattus norvegicus
0.485
-
Uracil cosubstrate: alpha-D-ribose-1-phosphate, enzyme from liver Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain embryo Gallus gallus
-
breast cancer cell negative correlation between UPase expression and the clinical outcome of breast cancer Homo sapiens
-
colonic cancer cell
-
Rattus norvegicus
-
colonic cancer cell RPMI Rattus norvegicus
-
embryo brain, liver and heart Gallus gallus
-
heart embryo Gallus gallus
-
liver
-
Rattus norvegicus
-
liver embryo Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + alpha-D-ribose-1-phosphate
-
Homo sapiens 5-fluorouridine + phosphate
-
?
5-fluorouracil + alpha-D-ribose-1-phosphate
-
Rattus norvegicus 5-fluorouridine + phosphate
-
?
uracil + alpha-D-ribose 1-phosphate
-
Homo sapiens uridine + phosphate
-
?
uracil + alpha-D-ribose 1-phosphate
-
Rattus norvegicus uridine + phosphate
-
?

Synonyms

Synonyms Comment Organism
UPase
-
Gallus gallus
UPase
-
Homo sapiens
UPase
-
Rattus norvegicus