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Literature summary for 2.4.2.3 extracted from

  • El Kouni, M.H.; Fardos, N.M.; Naguib, F.N.M.; Niedzwicki, J.G.; Iltzsch, M.H.; Cha, S.
    Uridine phosphorylase from Schistosoma mansoni (1988), J. Biol. Chem., 263, 6081-6086.
    View publication on PubMed
Search for more literature for 2.4.2.3

Inhibitors

Inhibitors Comment Organism Structure
2,2'-Anhydro-5-ethyluridine
-
 Schistosoma mansoni
5-(Benzyloxybenzyloxybenzyl)acyluridine
-
 Schistosoma mansoni
Benzylacyclouridines
-
 Schistosoma mansoni
deoxythymidine
-
 Schistosoma mansoni
phosphate substrate inhibition above 10 mM Schistosoma mansoni
uridine substrate inhibition Schistosoma mansoni

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Schistosoma mansoni

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
56000
-
 gel filtration Schistosoma mansoni

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
uridine + phosphate Schistosoma mansoni enzyme of pyrimidine salvage pathway uracil + alpha-D-ribose 1-phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Schistosoma mansoni
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Schistosoma mansoni

Reaction

Reaction Comment Organism Reaction ID
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate sequential mechanism Schistosoma mansoni
a

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Schistosoma mansoni

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxyuridine + phosphate
-
 Schistosoma mansoni uracil + deoxyribose 1-phosphate
-
 r
additional information no substrate: cytidine Schistosoma mansoni ?
-
 ?
additional information no substrates: cytosine, deoxycytidine, orotidine Schistosoma mansoni ?
-
 ?
thymidine + phosphate
-
 Schistosoma mansoni thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
 ?
uridine + phosphate
-
 Schistosoma mansoni uracil + alpha-D-ribose 1-phosphate
-
 r
uridine + phosphate enzyme of pyrimidine salvage pathway Schistosoma mansoni uracil + alpha-D-ribose 1-phosphate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information
-
 Schistosoma mansoni