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Literature summary for 2.4.2.3 extracted from

  • Pizzorno, G.; Cao, D.; Leffert, J.J.; Russell, R.L.; Zhang, D.; Handschumacher, R.E.
    Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update (2002), Biochim. Biophys. Acta, 1587, 133-144.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
5-benzylacyclouridine 0.01 mM, 90% inhibition of normal tissues, 40-60% inhibition of carcinoma tissue Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasmic membrane
-
Homo sapiens
-
-
cytoskeleton associated with intermediate filament vimentin in fibroblasts and colon 26 cells Mus musculus 5856
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33000
-
4 * 33000 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
NIH 3T3
-

Reaction

Reaction Comment Organism Reaction ID
uridine + phosphate = uracil + alpha-D-ribose 1-phosphate ordered bi-bi mechanism, phosphate binds before uridine and alpha-D-ribose 1-phosphate is released after uracil Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Mus musculus
-
additional information present in all human tissue and tumors Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thymidine + phosphate to a lesser extent compared to uridine Mus musculus thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?
thymidine + phosphate to a lesser extent compared to uridine Homo sapiens thymine + 2-deoxy-alpha-D-ribose 1-phosphate
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 33000 Homo sapiens