Literature summary for 2.4.2.26 extracted from

Venkatesan, N.; Barre, L.; Bourhim, M.; Magdalou, J.; Mainard, D.; Netter, P.; Fournel-Gigleux, S.; Ouzzine, M.
Xylosyltransferase-I regulates glycosaminoglycan synthesis during the pathogenic process of human osteoarthritis (2012), PLoS ONE, 7, e34020.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q86Y38	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cartilage	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
XT-I	-	Homo sapiens
xylosyltransferase-I	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	XT-I gene expression is down-regulated by IL-1beta	down
Homo sapiens	XT-I gene expression is up-regulated by TGF-beta1	up

General Information

General Information	Comment	Organism
physiological function	the role of XT-I in osteoarthritis disease is examined. XT-I regulates glycosaminoglycan synthesis in human cartilage during early onset and late stage of osteoarthritis disease. Expression of XT-I gene is regulated by IL-1beta and by TGF-beta1. Forced expression of this enzyme by gene transfer in late stage osteoarthritis cartilage enhances glycosaminoglycan synthesis and stimulates cartilage repair	Homo sapiens

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Release 2023.1 (January 2023)