Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.2.26 extracted from

  • Voglmeir, J.; Voglauer, R.; Wilson, I.B.
    XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity (2007), J. Biol. Chem., 282, 5984-5990.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.2.26

Cloned(Commentary)

Cloned (Comment) Organism
expressed in the xylosyltransferase-deficient pgsA-745 (S745) CHO cell line and in Pichia pastoris Homo sapiens
expression in Pichia pastoris. Soluble form of human XT-II is expressed in the xylosyltransferase-deficient pgsA-745 (S745) Chinese hamster ovary cell line Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.25
-
 UDP-D-xylose about Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information active in the absence of any added cation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens first enzyme required for the generation of chondroitin and heparan sulfate glycosaminoglycan chains of proteoglycans ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86Y38
-
-
Homo sapiens Q9H1B5
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information first enzyme required for the generation of chondroitin and heparan sulfate glycosaminoglycan chains of proteoglycans Homo sapiens ?
-
 ?
UDP-D-xylose + bikunin
-
 Homo sapiens UDP + D-xylosyl-bikunin
-
 ?
UDP-D-xylose + DDDSIEGSGGR
-
 Homo sapiens UDP + DDDSIEG(D-xylosyl)SGGR
-
 ?
UDP-D-xylose + DDDSIEGSGGR syndecan peptide substrate Homo sapiens UDP + DDDSIEG(D-xylosyl)SGGR
-
 ?
UDP-D-xylose + DSISGDDLGSGDLGSGDFQR
-
 Homo sapiens ?
-
 ?
UDP-D-xylose + DSISGDDLGSGDLGSGDFQR
-
 Homo sapiens UDP + ?
-
 ?
UDP-D-xylose + QEEEGSGGGGQR
-
 Homo sapiens UDP + QEEEG(D-xylosyl)SGGGGQR
-
 ?

Synonyms

Synonyms Comment Organism
peptide O-xylosyltransferase
-
 Homo sapiens
peptide-O-xylosyltransferase
-
 Homo sapiens
XT-I
-
 Homo sapiens
XT-I isozyme Homo sapiens
XT-II
-
 Homo sapiens
XT-II isozyme Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Homo sapiens

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
15 37 15°C: about 40% of maximal activity, 37°C: maximal activity Homo sapiens
16 37
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9 pH 6.5: about 60% of maximal activity, pH 9.0: about 60% of maximal activity Homo sapiens
6.5 8.5 pH 6.5: about 70% of maximal activity, pH 8.5: about 60% of maximal activity Homo sapiens