Application | Comment | Organism |
---|---|---|
medicine | the enzyme lacks a mammalian counterpart and is, therefore, a potential target for antiparasitic therapy | Leishmania donovani |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Leishmania donovani |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0071 | - |
xanthine | - |
Leishmania donovani | |
0.448 | - |
hypoxanthine | - |
Leishmania donovani |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania donovani | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Leishmania donovani |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-phospho-alpha-D-ribose 1-diphosphate + guanine | - |
Leishmania donovani | GMP + diphosphate | - |
? | |
5-phospho-alpha-D-ribose 1-diphosphate + hypoxanthine | - |
Leishmania donovani | IMP + diphosphate | - |
? | |
5-phospho-alpha-D-ribose 1-diphosphate + xanthine | - |
Leishmania donovani | 9-(5-phospho-beta-D-ribosyl)xanthine + diphosphate | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.6 | - |
hypoxanthine | - |
Leishmania donovani | |
3.5 | - |
xanthine | - |
Leishmania donovani |