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Literature summary for 2.4.2.2 extracted from

  • Nishioka, M.; Miyamoto, H.; Kurita, N.; Higashijima, J.; Yoshikawa, K.; Miyatani, T.; Shimada, M.
    Pyrimidine nucleoside phosphorylase and dihydropyrimidine dihydrogenase activities as predictive factors for the efficacy of doxifluridine together with mitomycin C as adjuvant chemotherapy in primary colorectal cancer (2007), Hepatogastroenterology, 54, 1089-1093.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyrimidine nucleoside + phosphate Homo sapiens most pyrimidine nucleosides except for 4-amino-substituted species like deoxycytidine pyrimidine base + alpha-D-ribose 1-phosphate or alpha-D-deoxyribose 1-phosphate r

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell PyNPase level quantified by sandwich ELISA using monoclonal anti-human thimidine phosphorylase antibodies 104B and 232-2, no association between PyNPase level and recurrence, disease-free survival at year 2.2 better with low PyNPase levels and high PyNPase-to-dihydropyrimidine dihydrogenase ratio Homo sapiens
-
colorectum PyNPase level quantified by sandwich ELISA using monoclonal anti-human thimidine phosphorylase antibodies 104B and 232-2 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5'-deoxy-5-fluorouridine + phosphate
-
Homo sapiens 5-fluorouracil + alpha-D-deoxyribose 1-phosphate 5-fluorouracil is a chemotherapeutic agent and inactivated by dihydropyrimidine dihydrogenase activity ?
pyrimidine nucleoside + phosphate most pyrimidine nucleosides except for 4-amino-substituted species like deoxycytidine Homo sapiens pyrimidine base + alpha-D-ribose 1-phosphate or alpha-D-deoxyribose 1-phosphate r

Synonyms

Synonyms Comment Organism
pynpase
-
Homo sapiens
pyrimidine nucleoside phosphorylase
-
Homo sapiens