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Literature summary for 2.4.2.19 extracted from

  • Sorci, L.; Blaby,I.K.; Rodionova, I.A.; De Ingeniis, J.; Tkachenko, S.; de Crécy-Lagard, V.; Osterman, A.L.
    uinolinate salvage and insights for targeting NAD biosynthesis in group A streptococci (2013), J. Bacteriol., 195, 726-732.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
pyridine-2,3-dicarboxylate 37°C, pH 7.5 Streptococcus pyogenes

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
31700
-
calculated from amino acid sequence Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate Streptococcus pyogenes
-
nicotinate D-ribonucleotide + diphosphate + CO2
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate Streptococcus pyogenes ATCC BAA-946
-
nicotinate D-ribonucleotide + diphosphate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes Q5XBL7 serotype M6
-
Streptococcus pyogenes ATCC BAA-946 Q5XBL7 serotype M6
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Streptococcus pyogenes nicotinate D-ribonucleotide + diphosphate + CO2
-
?
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Streptococcus pyogenes ATCC BAA-946 nicotinate D-ribonucleotide + diphosphate + CO2
-
?

Synonyms

Synonyms Comment Organism
M6_Spy1061 locus name Streptococcus pyogenes
sp.NadC
-
Streptococcus pyogenes

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6
-
pyridine-2,3-dicarboxylate 37°C, pH 7.5 Streptococcus pyogenes