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Literature summary for 2.4.2.19 extracted from

  • Shibata, K.; Iwai, K.
    Effect of 5-phosphoribosyl-1-pyrophosphate on crystalline quinolinate phosphoribosyltransferase activities from hog kidney and hog liver (1980), Agric. Biol. Chem., 44, 2785-2791.
No PubMed abstract available

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
5-phosphoribosyl-1-diphosphate inhibition at alkaline pH and at physiological pH, pH 7.4, but not at an acidic pH, competitive for quinolinate. In presence of 30% glycerol, both the kidney and liver enzyme are inhibited, even at acidic pH Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-
liver
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0227 0.0919 enzyme from kidney Sus scrofa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate
-
Sus scrofa nicotinate D-ribonucleotide + diphosphate + CO2
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
in presence of 1 mM 5-phospho-alpha-D-ribose 1-diphosphate, enzyme from kidney Sus scrofa
6
-
in presence of 1 mM 5-phospho-alpha-D-ribose 1-diphosphate, enzyme from liver Sus scrofa
9
-
in presence of 0.4 mM 5-phospho-alpha-D-ribose 1-diphosphate, enzyme from kidney and liver Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.05
-
5-phosphoribosyl-1-diphosphate enzyme from liver Sus scrofa
0.8
-
5-phosphoribosyl-1-diphosphate enzyme from kidney Sus scrofa