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Literature summary for 2.4.2.14 extracted from
- Mechanisms of inhibition of amido phosphoribosyltransferase from mouse L1210 leukemia cells (1997), Biochemistry, 36, 6377-6383.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| AMP | competitive vs. 5-phospho-alpha-D-ribose 1-diphosphate, noncompetitive vs. glutamine | Mus musculus |  |
| piritrexim | noncompetitive vs. 5-phospho-alpha-D-ribose 1-diphosphate, binds with positive cooperativity at 2 allosteric sites of an inactive dimer | Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| additional information | - |
partially purified enzyme shows 3 molecular forms: an inactive tetramer formed in the presence of AMP, an active dimer formed with 5-phospho-alpha-D-ribose 1-diphosphate and an inactive dimer formed with piritrexim | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leukemia cell | L1210 leukemia cells | Mus musculus | - |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
AMP | - |
Mus musculus | |
| 0.066 | - |
piritrexim | - |
Mus musculus | |
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