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Literature summary for 2.4.2.12 extracted from

  • Tan, B.; Young, D.; Lu, Z.; Wang, T.; Meier, T.; Shepard, R.; Roth, K.; Zhai, Y.; Huss, K.; Kuo, M.; Gillig, J.; Parthasarathy, S.; Burkholder, T.; Smith, M.; Geeganage, S.; Zhao, G.
    Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: Metabolic basis and potential clinical implications (2013), J. Biol. Chem., 288, 3500-3511.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
FK866 specific and potent inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens
-
nicotinamide D-ribonucleotide + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P43490
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell
-
Homo sapiens
-
BxPC-3 cell
-
Homo sapiens
-
culture condition:McCoys 5A medium-grown cell
-
Homo sapiens
-
DLD-1 cell
-
Homo sapiens
-
HCC-1937 cell
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
HT-29 cell
-
Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
MDA-MB-468 cell
-
Homo sapiens
-
SUM-149 cell
-
Homo sapiens
-
SW-480 cell
-
Homo sapiens
-
U-87MG cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nicotinamide + 5-phospho-alpha-D-ribose 1-diphosphate
-
Homo sapiens nicotinamide D-ribonucleotide + diphosphate
-
?

Synonyms

Synonyms Comment Organism
Nampt
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inhibition is responsible for ATP depletion, metabolic perturbation, and subsequent tumor growth inhibition Homo sapiens
physiological function the enzyme catalyzes the first rate-limiting step in converting nicotinamide to NAD+, essential for cellular metabolism, energy production, and DNA repair Homo sapiens