Literature summary for 2.4.2.12 extracted from

Colombano, G.; Travelli, C.; Galli, U.; Caldarelli, A.; Chini, M.G.; Canonico, P.L.; Sorba, G.; Bifulco, G.; Tron, G.C.; Genazzani, A.A.
A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry (2010), J. Med. Chem., 53, 616-623.

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Inhibitors

Inhibitors	Comment	Organism	Structure
N-biphenyl-2-yl-8-(4-pyridin-3-yl-1H-1,2,3-triazol-1-yl)octanamide	displays an IC50 for cytotoxicity in vitro of 3.8 nM and an IC50 for NAD depletion of 3.0 nM. Compound induces autophagic cell death	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P43490	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SH-SY5Y cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)