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Literature summary for 2.4.2.12 extracted from

  • Kim, M.K.; Lee, J.H.; Kim, H.; Park, S.J.; Kim, S.H.; Kang, G.B.; Lee, Y.S.; Kim, J.B.; Kim, K.K.; Suh, S.W.; Eom, S.H.
    Crystal structure of visfatin/pre-B cell colony-enhancing factor 1/nicotinamide phosphoribosyltransferase, free and in complex with the anti-cancer agent FK-866 (2006), J. Mol. Biol., 362, 66-77.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Rattus norvegicus

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging drop vapor diffusion method, crystallization of apoenzyme and complex with either nicotinamide mononucleotide or the NAmPRTase inhibitor FK-866 Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
FK-866 the nicotinamide-binding site is important for inhibition by FK-866 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus visfatin mimics insulin signaling by binding to the insulin receptor with an affinity similar to that of insulin and does not share the binding site with insulin on the insulin receptor ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q80Z29
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-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information visfatin mimics insulin signaling by binding to the insulin receptor with an affinity similar to that of insulin and does not share the binding site with insulin on the insulin receptor Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
nicotinamide phosphoribosyltransferase
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Rattus norvegicus
pre-B cell colony-enhancing factor 1
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Rattus norvegicus
Visfatin
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Rattus norvegicus