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Literature summary for 2.4.2.10 extracted from
- Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase (2012), Eur. J. Med. Chem., 54, 113-122.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,6-dihydroxypyridine-4-carboxylic acid | competitive to orotate, uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis |  |
| 3-(2-hydroxybenzylidene)-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid | competitive to orotate, uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis | |
| 3-benzylidene-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid | competitive to orotate, uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis | |
| 6-hydroxy-5-((2-hydroxyethylamino)methyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid | competitive to orotate, uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate | Mycobacterium tuberculosis | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mycobacterium tuberculosis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| orotate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Mycobacterium tuberculosis | orotidine 5'-phosphate + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| orotate phosphoribosyltransferase | - |
Mycobacterium tuberculosis |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00019 | - |
3-benzylidene-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid | competitive to orotate, pH 8.0, 25°C | Mycobacterium tuberculosis | |
| 0.00025 | - |
2,6-dihydroxypyridine-4-carboxylic acid | competitive to orotate, pH 8.0, 25°C | Mycobacterium tuberculosis | |
| 0.0062 | - |
6-hydroxy-5-((2-hydroxyethylamino)methyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid | competitive to orotate, pH 8.0, 25°C | Mycobacterium tuberculosis | |
| 0.0065 | - |
3-benzylidene-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid | uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate, pH 8.0, 25°C | Mycobacterium tuberculosis | |
| 0.0074 | - |
3-(2-hydroxybenzylidene)-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid | competitive to orotate, pH 8.0, 25°C | Mycobacterium tuberculosis | |
| 0.0082 | - |
2,6-dihydroxypyridine-4-carboxylic acid | uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate, pH 8.0, 25°C | Mycobacterium tuberculosis | |
| 0.0135 | - |
6-hydroxy-5-((2-hydroxyethylamino)methyl)-2-oxo-1,2-dihydropyridine-4-carboxylic acid | uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate, pH 8.0, 25°C | Mycobacterium tuberculosis | |
| 0.014 | - |
3-(2-hydroxybenzylidene)-2,6-dioxo-1,2,3,6-tetrahydropyridine-4-carboxylic acid | uncompetitive to 5-phospho-alpha-D-ribose 1-diphosphate, pH 8.0, 25°C | Mycobacterium tuberculosis | |
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