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Literature summary for 2.4.2.10 extracted from
- Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy (2008), BMC Cancer, 8, 188.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | OPRT activity is significantly lower in tumors with lymph node metastasis than in tumors lacking lymph node metastasis, thus OPRT activity level in tumor tissue may be an important prognostic factor for survival in Dukes B and C colorectal carcinoma cells with radical resection and adjuvant chemotherapy with orally administered tegafur/uracil | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colorectal cancer cell | Dukes B and C colorectal carcinoma cells | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| orotate + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | orotidine 5'-phosphate + diphosphate | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OPRT | - |
Homo sapiens |
| orotidine 5'-monophosphate pyrophosphorylase | - |
Homo sapiens |
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