Application | Comment | Organism |
---|---|---|
diagnostics | OPRT and DPD are valuable prognostic markers in gastric cancer | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | the activating OPRT and its antagonist the catabolizing dihydropyrimidine dehydrogenase play important roles in 5-fluorouracil metabolism, overview | 5-fluorouridine 5'-phosphate + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
gastric cancer cell | 221 specimen, expression profile of the enzyme and its antagonist dihydropyrimidine dehydrogenase both active in 5-fluorouracil metabolism, the enzyme expression levels correlate, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | 5-fluorouridine 5'-phosphate + diphosphate | - |
? | |
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate | the activating OPRT and its antagonist the catabolizing dihydropyrimidine dehydrogenase play important roles in 5-fluorouracil metabolism, overview | Homo sapiens | 5-fluorouridine 5'-phosphate + diphosphate | - |
? |