Any feedback?
Literature summary for 2.4.2.10 extracted from
- Correlation between expression of orotate phosphoribosyl transferase and 5-fluorouracil sensitivity, as measured by apoptosis index in colorectal cancer tissue (2005), Int. J. Gastrointest. Cancer, 35, 197-203.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate | Homo sapiens | - |
5-fluorouridine 5'-phosphate + diphosphate | - |
? |  |
| additional information | Homo sapiens | the enzyme expression is weakly correlated to 5-fluorouracil sensitivity and apoptotic cell rate, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colonic cancer cell | colorectal cancer tissue | Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
enzyme expression rate in tumor tissue with or without treatment with 5-fluorouracil | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate | - |
Homo sapiens | 5-fluorouridine 5'-phosphate + diphosphate | - |
? | |
| additional information | the enzyme expression is weakly correlated to 5-fluorouracil sensitivity and apoptotic cell rate, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| OPRT | - |
Homo sapiens |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
