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Literature summary for 2.4.2.10 extracted from

  • Ochiai, T.; Nishimura, K.; Noguchi, H.; Kitajima, M.; Tsukada, A.; Watanabe, E.; Nagaoka, I.; Futagawa, S.
    Prognostic impact of orotate phosphoribosyl transferase among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy (2006), Int. J. Cancer, 118, 3084-3088.
    View publication on PubMed
Search for more literature for 2.4.2.10

Application

Application Comment Organism
diagnostics OPRT activity in tumor tissue is a predictor of prognosis in resectable CRC patients treated by oral 5-fluorouracil-based adjuvant chemotherapy, and is useful to pick-up high risk patients independent from known prognosis factors Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate Homo sapiens the enzyme is involved in the de novo biosynthesis of pyrimidine nucleotides, main enzyme involved in phosphoribosylation of 5-fluorouracil, an essential step that leads to tumor growth inhibition 5-fluorouridine 5'-phosphate + diphosphate
-
 ?
additional information Homo sapiens the enzyme is associated with thymidylate synthase and dihydropyrimidine dehydrogenase in resectable colorectal cancer, overview, prognostic impact of the enzyme among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-
colonic cancer cell in resectable colorectal cancer Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate
-
 Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
 ?
5-fluorouracil + 5-phospho-alpha-D-ribose 1-diphosphate the enzyme is involved in the de novo biosynthesis of pyrimidine nucleotides, main enzyme involved in phosphoribosylation of 5-fluorouracil, an essential step that leads to tumor growth inhibition Homo sapiens 5-fluorouridine 5'-phosphate + diphosphate
-
 ?
additional information the enzyme is associated with thymidylate synthase and dihydropyrimidine dehydrogenase in resectable colorectal cancer, overview, prognostic impact of the enzyme among 5-fluorouracil metabolic enzymes in resectable colorectal cancers treated by oral 5-fluorouracil-based adjuvant chemotherapy, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
OPRT
-
 Homo sapiens
orotate phosphoribosyl transferase
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens