Literature summary for 2.4.2.10 extracted from

Javaid, Z.Z.; el Kouni, M.H.; Iltzsch, M.H.
Pyrimidine nucleobase ligands of orotate phosphoribosyltransferase from Toxoplasma gondii (1999), Biochem. Pharmacol., 58, 1457-1466.

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Inhibitors

Inhibitors	Comment	Organism	Structure
1-deazaorotic acid	-	Toxoplasma gondii
5-azaorotic acid	-	Toxoplasma gondii
additional information	structural features of pyrimidine nucleobase inhibitors	Toxoplasma gondii
Uracil	-	Toxoplasma gondii

Organism

Organism	UniProt	Comment	Textmining
Toxoplasma gondii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
orotate + 5-phospho-alpha-D-ribose 1-diphosphate	-	Toxoplasma gondii	orotidine 5'-phosphate + diphosphate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00047	-	1-deazaorotic acid	-	Toxoplasma gondii
0.0021	-	5-azaorotic acid	-	Toxoplasma gondii

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Release 2023.1 (January 2023)